Objective: To perform a Meta-analysis on hepatitis B surface antigen (HBsAg)-positive rates among general Chinese population aged 1-59 years. Methods: We systemically reviewed the related data (January 2007 to August 2016) published from Chinese National Knowledge Infrastructure (CNKI), VIP, and PubMed. We also assessed the HBsAg-positive rates among general Chinese populations aged 1-59 years, using a random effects regression model with the comprehensive Meta-analysis software 2.2. Results: A total of 46 papers were finally included, with a total sample size of 625 053 individuals. Results from the Meta-analysis showed that the overall combined HBsAg-positive rate was 5.7 % (95 %CI : 4.8 % -6.6 % ) among general Chinese populations aged 1-59 years. When comparing the HBsAg-positive rates in different regions, data showed that the HBsAg-positive rate of was higher in the mid-western areas (6.3 % , 95 %CI : 4.9 % -8.0 % ) than in the eastern areas (5.5 % , 95 %CI : 4.4 % -6.8 % ). Results showed that HBsAg-positive rates was higher in males (6.1 % , 95 %CI : 5.3 % -7.0 % ) than in females (4.8 % , 95 %CI : 4.2 % -5.5 % ). As for the HBsAg-positive rates in different time periods, data showed positive rate of 6.3 % (95 %CI : 5.5 % -7.2 % ) in 2007-2009, 5.9 % (95 %CI : 4.4 % -8.0 % ) in 2010-2012 and 3.5 % (95 %CI : 2.0 % -6.1 % ) in 2013- 2016, respectively. Conclusion: The prevalence of hepatitis B virus infection was decreasing between 2007 and 2016 in China, making the country an intermediate endemic area on HBV.
【저자키워드】 Meta-analysis, positive rate, HBsAg,