Abstract
With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies.
Keywords: COVID-19; SARS-CoV-2; immunity; interferon.
【저자키워드】 COVID-19, SARS-CoV-2, Immunity, interferon., 【초록키워드】 Vaccine, Pathogenesis, Antiviral, COVID-19 pandemic, antiviral drugs, interferon, variants, antiviral drug, immune evasion, viral replication, Therapeutic strategies, understanding, IFN, signaling pathways, mechanism, Signaling, innate immune, Interaction, Innate, host defense, interferon pathway, SARS-CoV-2 proteins, host cell, Immune receptor, effort, SARS-CoV-2 protein, Defense, Host, effective, develop, coronavirus, determine, evade, 【제목키워드】 Antiviral, interferon pathway,