Abstract
Objectives: This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months.
Methods: Next-generation sequencing and a bioinformatic approach were applied to analyse the data.
Results: In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others.
Conclusions: Zoonotic spill-over of SARS-CoV-2 can occur from mink to human.
Keywords: Mink; SARS-CoV-2; Spill-over; Transmission; Zoonoses.
【저자키워드】 zoonoses, SARS-CoV-2, Transmission, mink, spill-over, 【초록키워드】 zoonoses, coronavirus, Mutation, Human, Sequencing, variant, severe acute respiratory syndrome Coronavirus, Y453F, mink, zoonotic, Next-generation sequencing, adaptation, asymptomatic patient, S gene, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, positive, isolate, approach, applied, occur, 【제목키워드】 virus,