Abstract
Background: COVID-19 is an infectious disease which caused a pandemic with many diseases and fatalities. This new variant of coronavirus called SARS-CoV-2 and is primarily characterized by respiratory symptoms. There are some data indicating that LDL-cholesterol (LDL-C) as well as HDL-cholesterol (HDL-C) levels are inversely correlated to disease severity and could act as a predictor for disease progression and unfavorable prognosis. However, the results of some other studies do not confirm this. This current study aimed to provide an answer to this question.
Methods: This prospective, single-center study analyzed 367 confirmed COVID-19 patients to find whether there are any differences in plasma lipoproteins between survivors and non-survivors patients or between the patients with a “duration of ≤10 days intensive unit care (ICU) stay” and patients with a “duration of >10 days ICU stay”.
Results: No association between any lipid/lipoprotein parameter and the severity of COVID-19 could be found but survivors and non-survivors did differ concerning total cholesterol and LDL-C levels.
Conclusion: Multivariate cox regression analysis could not prove any association between lipids/lipoproteins and severe events in COVID-19 patients. Significantly less non-survivors with COVID-19 were taking atorvastatin than survivors which is consistent with the majority of previous findings.
Keywords: Atorvastatin; COVID-19; HDL-cholesterol; LDL-cholesterol; Statins.
【저자키워드】 COVID-19, statins., LDL-cholesterol, atorvastatin, HDL-cholesterol, 【초록키워드】 SARS-CoV-2, coronavirus, pandemic, Prognosis, Lipoproteins, disease severity, variant, Infectious disease, ICU, Disease progression, severity of COVID-19, Patient, LDL-cholesterol, atorvastatin, HDL-cholesterol, cholesterol, LDL-C, disease, Intensive, Care, statins, COVID-19 patients, association, Total cholesterol, COVID-19 patient, respiratory symptoms, regression analysis, Non-survivors, HDL-C, multivariate, single-center study, multivariate Cox regression analysis, plasma lipoproteins, survivor, parameter, event, non-survivor, analyzed, caused, the patient, characterized, majority, less, question, correlated, concerning, plasma lipoprotein, with COVID-19, 【제목키워드】 severity, plasma, association,