Abstract
The Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the biggest public health challenge the world has witnessed in the past decades. SARS-CoV-2 undergoes constant mutations and new variants of concerns (VOCs) with altered transmissibility, virulence, and/or susceptibility to vaccines and therapeutics continue to emerge. Detailed analysis of host factors involved in virus replication may help to identify novel treatment targets. In this study, we dissected the metabolome derived from COVID-19 patients to identify key host factors that are required for efficient SARS-CoV-2 replication. Through a series of metabolomic analyses, in vitro , and in vivo investigations, we identified ATP citrate lyase (ACLY) as a novel host factor required for efficient replication of SARS-CoV-2 wild-type and variants, including Omicron. ACLY should be further explored as a novel intervention target for COVID-19.
Keywords: ACLY; COVID-19; Delta; Omicron; SARS-CoV-2; metabolomics.
【저자키워드】 COVID-19, SARS-CoV-2, Delta, omicron, metabolomics., ACLY, 【초록키워드】 Treatment, coronavirus disease, public health, metabolomics, Coronavirus disease 2019, Vaccine, coronavirus, pandemic, Mutation, Therapeutics, susceptibility, variants of concern, Intervention, metabolome, in vitro, severe acute respiratory syndrome Coronavirus, omicron, variants, Transmissibility, VOCs, virus replication, targets, ATP, in vivo, virulence, SARS-CoV-2 replication, COVID-19 patients, Analysis, ACLY, COVID-19 patient, citrate, acute respiratory syndrome, Factor, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, help, wild-type, replication of SARS-CoV-2, Host, metabolomic, identify, caused, involved, required, analyses, 【제목키워드】 SARS-CoV-2 replication, targeting, inhibit,