Abstract
Although advanced age and presence of comorbidities significantly impact the variation observed in the clinical symptoms of COVID-19, it has been suggested that genetic variants may also be involved in the disease. Thus, the aim of this study was to perform a systematic review with meta-analysis of the literature to identify genetic polymorphisms that are likely to contribute to COVID-19 pathogenesis. Pubmed, Embase and GWAS Catalog repositories were systematically searched to retrieve articles that investigated associations between polymorphisms and COVID-19. For polymorphisms analyzed in 3 or more studies, pooled OR with 95% CI were calculated using random or fixed effect models in the Stata Software. Sixty-four eligible articles were included in this review. In total, 8 polymorphisms in 7 candidate genes and 74 alleles of the HLA loci were analyzed in 3 or more studies. The HLA-A*30 and CCR5 rs333Del alleles were associated with protection against COVID-19 infection, while the APOE rs429358C allele was associated with risk for this disease. Regarding COVID-19 severity, the HLA-A*33, ACE1 Ins, and TMPRSS2 rs12329760T alleles were associated with protection against severe forms, while the HLA-B*38, HLA-C*6, and ApoE rs429358C alleles were associated with risk for severe forms of COVID-19. In conclusion, polymorphisms in the ApoE, ACE1, TMPRSS2, CCR5, and HLA loci appear to be involved in the susceptibility to and/or severity of COVID-19.
【저자키워드】 TMPRSS2, 【초록키워드】 COVID-19, Meta-analysis, Clinical symptoms, susceptibility, Variation, Comorbidities, polymorphism, COVID-19 severity, alleles, systematic review, risk, Polymorphisms, COVID-19 pathogenesis, COVID-19 infection, severity of COVID-19, genetic variants, genetic polymorphisms, Genetic variant, GWAS, HLA, disease, CCR5, association, ApoE, HLA-B, Genetic polymorphism, candidate gene, ACE1, HLA-A, Repository, 95% CI, clinical symptom, advanced age, allele, severe forms of COVID-19, HLA-C, loci, article, random, Stata software, C allele, forms, analyzed, identify, significantly, involved, investigated, the disease, form, calculated, searched, contribute, suggested, fixed, eligible, presence of comorbidity, 【제목키워드】 Meta-analysis, susceptibility, polymorphism, COVID-19 disease,