Abstract
Background: Several neurologic complications have been reported in close temporal association with both severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and following vaccination against SARS-CoV-2. Specifically, several cases of Guillain-Barré syndrome (GBS) have been reported in temporal relationship with COVID-19 vaccination, with two small case series describing a specific phenotype with bifacial weakness and paresthesia in the limbs.
Methods: We retrospectively collected patients who developed a new-onset neuromuscular disorder in the first 6 weeks after receiving a COVID-19 vaccine (either first or second dose). The patients were collected from one tertiary care centre and one secondary care centre from February to July 2021.
Results: We report eight patients who developed phenotypically diverse neuromuscular disorders in the weeks following COVID-19 vaccination, with a presumed immune-mediated etiology. In our case series, we report three patients with classical GBS, one patient with bifacial weakness with paresthesia variant of GBS, two patients with subacute-onset chronic inflammatory demyelinating polyneuropathy (CIDP), one patient with brachial plexopathy and one patient with subacute axonal sensorimotor polyneuropathy.
Conclusions: New-onset neuromuscular disorders with onset in the weeks after COVID-19 vaccination can include diverse phenotypes. A causal relationship between these disorders and the vaccine cannot be proven at present, and further epidemiological studies are needed to further investigate this association.
Keywords: CIDP; COVID-19; Guillain-Barré; Neuromuscular; Vaccine.
【저자키워드】 COVID-19, vaccine., CIDP, Guillain-Barré, Neuromuscular, 【초록키워드】 SARS-CoV-2, COVID-19 vaccine, vaccination, variant, Infection, Case series, COVID-19 vaccination, Patient, Complication, phenotype, etiology, Care, Guillain-barrè syndrome, Immune-mediated, association, Coronavirus-2, Inflammatory, Neuromuscular, can not, causal relationship, secondary care, Phenotypes, Polyneuropathy, acute respiratory syndrome, acute respiratory syndrome coronavirus, second dose, one patient, two patients, acute respiratory syndrome coronavirus-2, syndrome, weakness, Epidemiological study, disorder, neurologic, chronic inflammatory demyelinating polyneuropathy, paresthesia, limbs, classical, collected, include, reported, eight, receiving, case sery, the vaccine, brachial, with COVID-19, 【제목키워드】 Patient, Complication, eight,