[저자] Satveer K. Mahil, Nick Dand, Kayleigh J. Mason, Zenas Z.N. Yiu, Teresa Tsakok, Freya Meynell, Bola Coker, Helen McAteer, Lucy Moorhead, Teena Mackenzie, Maria Teresa Rossi, Raquel Rivera, Emmanuel Mahe, Andrea Carugno, Michela Magnano, Giulia Rech, Esther A. Balogh, Steven R. Feldman, Claudia De La Cruz, Siew Eng Choon, Luigi Naldi, Jo Lambert, Phyllis Spuls, Denis Jullien, Hervé Bachelez, Devon E. McMahon, Esther E. Freeman, Paolo Gisondi, Luis Puig, Richard B. Warren, Paola Di Meglio, Sinéad M. Langan, Francesca Capon, Christopher E.M. Griffiths, Jonathan N. Barker, Catherine H. Smith,
PsoProtect study group‡ShahAadarshMRCPBareaAlbertoMScRomero-MatéAlbertoMDSingaporeAlekyaMDPaolinoAlexandraMRCPMwaleAliceBScMorales CallaghanAna MariaMDMartinezAnaMDDeCrescenzoAndrewMDPinkAndrew E.MRCP, PhDJonesAnnBScSergeantAnnMDEssexAnnetteRGNBewleyAnthonyFRCPMakrygeorgouAretiMBBSvan HuizenAstridMDPérez-SuárezBeatrizMD, PhDFaridaBenhadouMD, PhDClaréusBirgitta WilsonMDPrimsCarla TubauMDDavisCarrieMDQuinlanCatherineMRCPIMayburyCatrionaMRCP, PhDCesarGonzalez A.MDBarclayCharlotteBScGrecoClaudioMDBrassardDanielleMDCummingsDeannaBScKolliDeeptiMDDescampsVincentMD, PhDGenaoDiana RuizMDCarrasEfrossiniBSc, MRCPHawrylukElenaMD, PhDMartínez-GarcíaEliseoMD, PhDKlujszoElzbietaMDDwyerEmilyBScToniEmmanuelBScSonkolyEniköMD, PhDLoayzaEnriqueMDDaudénEstebanMD, PhDValenzuelaFernandoMDPopovGeorgiMD, PhDKingGeorgieMScCelineGirardMDAparicioGloriaMDJohnstonGraham A.FRCPCardozoGustavo AnibalMDPearsonIanMRCPYanguasIgnacioMDWeismanJamieMDCarolanJennifer E.MScHughesJennyFRCPOrtiz-SalvadorJose-MariaMD, PhDCarrascosaJose-ManuelMD, PhDSchwartzJoseph J.MDJacksonKarinaMScKerisitKathryn G.MD, MPHWuKeithMDAsfourLeilaMRCPde GraafLeontienMDLesortCécileMDMeulemanLieveMDEidsmoLivMD, PhDSkovLoneMD, PhDGribbenLorraineBScRustinMalcolmMDVelascoManelMDPanchalManishaMDLakhanManpreetMRCPFrancoManuel D.MDSvenssonMarie-LouiseBScVandaeleMarkMDMarovtMaruskaMD, PhDZargariOmidMDDe CasoPabloMDVarelaPauloMDJenkinPeterMD, FAADPhanCélineMDHamptonPhilipFRCP, PhDGoldsmithPortiaMD, FRCPBakRachelMDSpeeckaertReinhartMD, PhDRomitiRicardoMD, PhDWoolfRichardMRCP, PhDMercado-SedaRogelioMDKhatunRohimaBScCeovicRomanaMDTabernerRosaMDCohenRussell W.MD, FAADStefanescuSiminaMDKirkSarahBScReekenSaskiaBScAyobShantiMRCPPérez-BarrioSilviaMDPiasericoStefanoMD, PhDHoeySusannahMDTorresTiagoMD, PhDTalmeToomasMD, PhDDesaiTrupti V.MDvan GeestAdrienne J.MDKingVictoriaBScDi LerniaVitoMDKorejaZahiraBScHasabVito ZeeshaanMBBS
, Aadarsh Shah, Alberto Barea, Alberto Romero-Maté, Alekya Singapore, Alexandra Paolino, Alice Mwale, Ana Maria Morales Callaghan, Ana Martinez, Andrew DeCrescenzo, Andrew E. Pink, Ann Jones, Ann Sergeant, Annette Essex, Anthony Bewley, Areti Makrygeorgou, Astrid van Huizen, Beatriz Pérez-Suárez, Benhadou Farida, Birgitta Wilson Claréus, Carla Tubau Prims, Carrie Davis, Catherine Quinlan, Catriona Maybury, Gonzalez A. Cesar, Charlotte Barclay, Claudio Greco, Danielle Brassard, Deanna Cummings, Deepti Kolli, Vincent Descamps, Diana Ruiz Genao, Efrossini Carras, Elena Hawryluk, Eliseo Martínez-García, Elzbieta Klujszo, Emily Dwyer, Emmanuel Toni, Enikö Sonkoly, Enrique Loayza, Esteban Daudén, Fernando Valenzuela, Georgi Popov, Georgie King, Girard Celine, Gloria Aparicio, Graham A. Johnston, Gustavo Anibal Cardozo, Ian Pearson, Ignacio Yanguas, Jamie Weisman, Jennifer E. Carolan, Jenny Hughes, Jose-Maria Ortiz-Salvador, Jose-Manuel Carrascosa, Joseph J. Schwartz, Karina Jackson, Kathryn G. Kerisit, Keith Wu, Leila Asfour, Leontien de Graaf, Cécile Lesort, Lieve Meuleman, Liv Eidsmo, Lone Skov, Lorraine Gribben, Malcolm Rustin, Manel Velasco, Manisha Panchal, Manpreet Lakhan, Manuel D. Franco, Marie-Louise Svensson, Mark Vandaele, Maruska Marovt, Omid Zargari, Pablo De Caso, Paulo Varela, Peter Jenkin, Céline Phan, Philip Hampton, Portia Goldsmith, Rachel Bak, Reinhart Speeckaert, Ricardo Romiti, Richard Woolf, Rogelio Mercado-Seda, Rohima Khatun, Romana Ceovic, Rosa Taberner, Russell W. Cohen, Simina Stefanescu, Sarah Kirk, Saskia Reeken, Shanti Ayob, Silvia Pérez-Barrio, Stefano Piaserico, Susannah Hoey, Tiago Torres, Toomas Talme, Trupti V. Desai, Adrienne J. van Geest, Victoria King, Vito Di Lernia, Zahira Koreja, Vito Zeeshaan Hasab
[Category] MERS, SARS,
[Article Type] Clinical Trial
[Source] PMC
Background The multimorbid burden and use of systemic immunosuppressants in people with psoriasis may confer greater risk of adverse outcomes of coronavirus disease 2019 (COVID-19), but the data are limited. Objective Our aim was to characterize the course of COVID-19 in patients with psoriasis and identify factors associated with hospitalization. Methods Clinicians reported patients with psoriasis with confirmed/suspected COVID-19 via an international registry, Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection. Multiple logistic regression was used to assess the association between clinical and/or demographic characteristics and hospitalization. A separate patient-facing registry characterized risk-mitigating behaviors. Results Of 374 clinician-reported patients from 25 countries, 71% were receiving a biologic, 18% were receiving a nonbiologic, and 10% were not receiving any systemic treatment for psoriasis. In all, 348 patients (93%) were fully recovered from COVID-19, 77 (21%) were hospitalized, and 9 (2%) died. Increased hospitalization risk was associated with older age (multivariable-adjusted odds ratio [OR] = 1.59 per 10 years; 95% CI = 1.19-2.13), male sex (OR = 2.51; 95% CI = 1.23-5.12), nonwhite ethnicity (OR = 3.15; 95% CI = 1.24-8.03), and comorbid chronic lung disease (OR = 3.87; 95% CI = 1.52-9.83). Hospitalization was more frequent in patients using nonbiologic systemic therapy than in those using biologics (OR = 2.84; 95% CI = 1.31-6.18). No significant differences were found between classes of biologics. Independent patient-reported data (n = 1626 across 48 countries) suggested lower levels of social isolation in individuals receiving nonbiologic systemic therapy than in those receiving biologics (OR = 0.68; 95% CI = 0.50-0.94). Conclusion In this international case series of patients with moderate-to-severe psoriasis, biologic use was associated with lower risk of COVID-19–related hospitalization than with use of nonbiologic systemic therapies; however, further investigation is warranted on account of potential selection bias and unmeasured confounding. Established risk factors (being older, being male, being of nonwhite ethnicity, and having comorbidities) were associated with higher hospitalization rates.
All Keywords
【저자키워드】 COVID-19, Risk factors, Hospitalization, immunosuppressants, biologics, OR, odds ratio, IQR, interquartile range, psoriasis, BMI, Body mass index, IBD, Inflammatory bowel disease, IMID, Immune-mediated inflammatory disease, PsoProtect, Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection,