In 70 chronic hepatitis B patients with hepatitis B surface antigen seroclearance during nucleos(t)ide analogue therapy, response was sustained in all 54 patients who discontinued treatment. Clinically significant relapses as indicated by high hepatitis B virus DNA and ALT levels were not observed. Anti-HBs positivity may not be required to ensure sustained off-treatment response.
All Keywords
【저자키워드】 Chronic Hepatitis B, Nucleos(t)ide analogue, treatment discontinuation, HBsAg negative, off-treatment response,
【저자키워드】 Chronic Hepatitis B, Nucleos(t)ide analogue, treatment discontinuation, HBsAg negative, off-treatment response,