Abstract
For COVID-19 (Coronavirus Disease-2019) cases, detecting host-based factors that predispose to infection is a very important research area. In this study, the aim is to investigate the MBL2 and NOS3 gene polymorphisms in COVID-19 patients with lung involvement, whose first nasopharyngeal PCR results were negative. Seventy-nine patients diagnosed with COVID-19 between April-June 2020 who were admitted to a university hospital, and 100 healthy controls were included. In the first statistical analysis performed between PCR-positive, CT-negative and PCR-negative, CT-positive patients; the AB of MBL2 genotype was significantly higher in the first group (p = 0.049). The B allele was also significantly higher in the same subgroup (p = 0.001). The absence of the AB genotype was found to increase the risk of CT positivity by 6.9 times. The AB genotype of MBL2 was higher in healthy controls (p = 0.006). The absence of the AB genotype was found to increase the risk of CT positivity; also, it can be used for early detection and isolation of patients with typical lung involvement who had enough viral loads, but whose initial PCR results were negative.
Keywords: COVID-19; CT; PCR; endothelial nitric oxide synthase (eNOS); mannose-binding lectin 2 (MBL2).
【저자키워드】 COVID-19, CT, PCR, Endothelial nitric oxide synthase (eNOS), mannose-binding lectin 2 (MBL2)., 【초록키워드】 coronavirus disease, nitric oxide, lung involvement, Infection, polymorphism, risk, coronavirus disease-2019, nasopharyngeal, Early detection, Research, Patient, Genotype, Isolation, MBL2, statistical analysis, COVID-19 patient, nitric oxide synthase, endothelial, Factor, healthy control, university hospital, PCR-positive, viral loads, mannose, healthy controls, allele, PCR-negative, NOS3, initial, performed, can be used, absence, significantly higher, diagnosed with COVID-19, 【제목키워드】 variant, Patient, investigation, functional gene,