Abstract
Generalized erythrodermic psoriasis (GEP) is a rare and potentially life-threatening variant of psoriasis. Possible triggers that have been identified to date include poorly controlled psoriasis, medications, abrupt discontinuation of anti-psoriatic treatment, and underlying systemic illnesses. However, vaccines have rarely been reported to exacerbate GEP. Herein, we report two unique cases with GEP exacerbated following a dose of the BNT162b2 mRNA vaccine for COVID-19 (as their second dose, the first being the mRNA-1273 vaccine). Based on our observations and a literature review, vaccination was considered the most likely trigger of GEP due to the close temporal relationship between the second vaccination and the onset of GEP.
Keywords: BNT162b2 vaccine; COVID-19; SARS-CoV-2 vaccination; generalized erythrodermic psoriasis; mRNA-1273 vaccine.
【저자키워드】 COVID-19, BNT162b2 vaccine, SARS-CoV-2 vaccination, generalized erythrodermic psoriasis, mRNA-1273 vaccine., 【초록키워드】 Treatment, SARS-CoV-2, Vaccine, BNT162b2 vaccine, vaccination, mRNA-1273, variant, medications, BNT162b2, mRNA, SARS-CoV-2 vaccination, BNT162b2 mRNA, BNT162b2 mRNA vaccine, dose, Trigger, psoriasis, erythrodermic psoriasis, observation, literature review, mRNA-1273 vaccine, second vaccination, second dose, illnesses, include, reported, exacerbated, unique, exacerbate, Generalized, potentially life-threatening, 【제목키워드】 vaccination, coronavirus 2, acute respiratory syndrome, triggered, Generalized,