Abstract
Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population. We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01-2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16-4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response.
Keywords: COVID-19; Genetics; Interferon; SARS-Cov-2.
【저자키워드】 COVID-19, interferon, genetics, SARS-CoV-2., 【초록키워드】 public health, SARS-CoV-2, IFITM3, Mortality, SARS-COV-2 infection, variant, interferon, risk factor, Clinical outcome, Probability, survival, membrane protein, Patient, Genotype, death, Hospital admission, Viral diseases, Plasma levels, Precision, higher risk, PCR-confirmed, individual, log-rank test, IFNγ, allele, heterogeneous, IFITM, significantly lower, COVID-19 phenotypes, examined, less, genotyped, subset, underlie, Plasma level, 【제목키워드】 Mortality, Genetic variant, transmembrane, with COVID-19,