Abstract
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin-angiotensin-aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis.
Keywords: Acute lung injury; Acute respiratory distress syndrome; Angiotensin-converting enzyme-2; COVID-19; SARS-CoV-2; rhACE2.
【저자키워드】 COVID-19, SARS-CoV-2, acute respiratory distress syndrome, acute lung injury, angiotensin-converting enzyme-2, rhACE2., 【초록키워드】 Respiratory distress syndrome, ACE2, acute respiratory distress syndrome, lung, ACE2 receptor, Proteins, cardiovascular system, Lung injury, medications, hypertension, aldosterone, acute lung injury, COVID-19 pathogenesis, pathophysiology, persistence, pathway, ACE2 receptors, receptor, molecular, correlation, angiotensin-converting enzyme-2, Angiotensin-converting enzyme, renin-angiotensin-aldosterone system, angiotensin, ACE, distress, manifestation, respiratory distress, Renin, these viruses, disorders, enzyme, human cells, SARS-CoV-2-infected patients, intake, viral particle, pandemic of COVID-19, researcher, ACE gene, Cell, virus, raised, question, homologue, genomic variant, raising, 【제목키워드】 ACE-2 receptor, understanding, pathogenesis of COVID-19, therapeutic intervention, approach,