Abstract
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a major public health challenge worldwide. Owing to the emergence of novel viral variants, the risks of reinfections and vaccine breakthrough infections has increased considerably despite a mass of vaccination. The formation of cytokine storm, which subsequently leads to acute respiratory distress syndrome, is the major cause of mortality in patients with COVID-19. Based on results of preclinical animal models and clinical trials of acute lung injury and acute respiratory distress syndrome, the immunomodulatory, tissue repair, and antiviral properties of MSCs highlight their potential to treat COVID-19. This review article summarizes the potential mechanisms and outcomes of MSC therapy in COVID-19, along with the pathogenesis of the SARS-CoV-2 infection. The properties of MSCs and lessons from preclinical animal models of acute lung injury are mentioned ahead. Important issues related to the use of MSCs in COVID-19 are discussed finally.
Keywords: COVID-19; acute lung injury; acute respiratory distress syndrome; cell therapy; mesenchymal stem cells.
【저자키워드】 COVID-19, acute respiratory distress syndrome, Cell therapy, acute lung injury, mesenchymal stem cells., 【초록키워드】 coronavirus disease, stem cells, public health, SARS-CoV-2, Respiratory distress syndrome, Coronavirus disease 2019, Cytokine storm, coronavirus, vaccination, clinical trial, pandemic, Pathogenesis, Mortality, acute respiratory distress syndrome, Cell therapy, SARS-COV-2 infection, Infection, lung, clinical trials, risk, Mesenchymal stem cells, MSCs, animal model, Lung injury, outcome, severe acute respiratory syndrome Coronavirus, acute lung injury, Reinfection, immunomodulatory, Viral variants, tissue repair, acute respiratory distress, MSC, vaccine breakthrough infections, antiviral property, respiratory distress, MSC therapy, acute respiratory syndrome, acute respiratory syndrome coronavirus, potential mechanism, acute respiratory syndrome coronavirus 2, mass, syndrome, antiviral properties, treat, potential mechanisms, Cell, vaccine breakthrough infection, highlight, caused, patients with COVID-19, the SARS-CoV-2, 【제목키워드】 immunomodulation, animal, Model, STEM, Preclinical,