Abstract
The exact duration of viable SARS-CoV-2 shedding in kidney transplant recipients (KTRs) remains unclear. Here, we retrospectively investigated this issue using cell cultures of SARS-CoV-2 RT-PCR-positive nasopharyngeal samples (n = 40) obtained from 16 KTRs with symptomatic COVID-19 up to 39 days from symptom onset. A length of viable SARS-CoV-2 shedding >3 weeks from the onset of symptoms was identified in four KTRs (25%). These results suggest that a significant proportion of KTRs can shed viable SARS-CoV-2 for at least 3 weeks, which may favor the emergence of new variants. Based on these data, we recommend prolonging the isolation of KTRs with COVID-19 until negative SARS-CoV-2 RT-PCR testing.
Keywords: clinical research/practice; complication: infectious; infection and infectious agents – viral; infectious disease; kidney transplantation/nephrology; translational research/science.
【저자키워드】 Infectious disease, clinical research/practice, infection and infectious agents - viral, translational research/science, kidney transplantation/nephrology, complication: infectious, 【초록키워드】 COVID-19, SARS-CoV-2, Infection, Infectious disease, variants, kidney, PCR testing, symptomatic, Cell culture, Isolation, Complication, SARS-CoV-2 RT-PCR, infectious, kidney transplant recipient, kidney transplant recipients, symptomatic COVID-19, infectious agents, infectious agent, symptom onset, RT-PCR testing, These data, Nasopharyngeal samples, favor, cell cultures, nasopharyngeal sample, proportion, investigated, onset of symptom, translational, with COVID-19, 【제목키워드】 SARS-CoV-2, kidney transplant recipient, with COVID-19,