Abstract
There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative, Nature 600, 472-477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. Pääbo, Nature 587, 610-612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an ∼27% lower risk of HIV infection.
Keywords: COVID-19; HIV; genetics.
All Keywords
【저자키워드】 COVID-19, HIV, Genetics., 【초록키워드】 variant, risk, outcome, genetics, DNA, expression, CCR5, Haplotype, HIV infection, chromosome 3, Nature, chromosome, carriers, lower risk, chemokine receptors, genetic risk factors, carrier, initiative, genetic risk factor, modulate, down-regulated, 【제목키워드】 severe COVID-19, genetic risk factor,
【저자키워드】 COVID-19, HIV, Genetics., 【초록키워드】 variant, risk, outcome, genetics, DNA, expression, CCR5, Haplotype, HIV infection, chromosome 3, Nature, chromosome, carriers, lower risk, chemokine receptors, genetic risk factors, carrier, initiative, genetic risk factor, modulate, down-regulated, 【제목키워드】 severe COVID-19, genetic risk factor,
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코로나19의 결과에 영향을 미치는 유전적 위험인자가 있다[COVID-19 Host Genetics Initiative, Nature 600, 472-477 (2021)]. 중증 COIVD-19의 주요 유전적 위험 인자는 3번 염색체에 있으며 네안데르탈인에게서 유전됩니다[H. Zeberg, S. Pääbo, Nature 587, 610-612 (2020)]. 위험 관련 DNA 세그먼트는 여러 케모카인 수용체의 발현을 조절하며, 그 중 CCR5는 COVID-19 위험 일배체형의 운반체에서 하향 조절되는 HIV에 대한 공동 수용체입니다. 여기에서 나는 위험 변이의 보균자가 HIV 감염 위험이 ~27% 낮다는 것을 보여줍니다.
{{ 키워드: }} 코로나19; HIV; 유전학.