Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient’s SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described.
Keywords: COVID-19; D614G; MIS-C; SARS-CoV-2; pseudotumor cerebri syndrome; viral lineage.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, MIS-C, D614G, pseudotumor cerebri syndrome, viral lineage., 【초록키워드】 coronavirus, Europe, SARS-COV-2 infection, children, Infection, severe acute respiratory syndrome Coronavirus, MIS-C, Spike protein, outbreak, D614G variant, Patient, Lineage, D614G, United States, disease, Inflammatory, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, syndrome, described, caused, the United State, the spike protein, predominant, complicate,
【저자키워드】 COVID-19, SARS-CoV-2, MIS-C, D614G, pseudotumor cerebri syndrome, viral lineage., 【초록키워드】 coronavirus, Europe, SARS-COV-2 infection, children, Infection, severe acute respiratory syndrome Coronavirus, MIS-C, Spike protein, outbreak, D614G variant, Patient, Lineage, D614G, United States, disease, Inflammatory, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, syndrome, described, caused, the United State, the spike protein, predominant, complicate,
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소아 다기관 염증 증후군(MIS-C)은 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 감염을 복잡하게 만들 수 있는 새로 인식된 질병 과정입니다. 우리는 2020년 2월에 발생한 MIS-C의 가장 초기 사례라고 생각하는 것을 제시합니다. 우리 환자의 SARS-CoV-2 감염은 스파이크 단백질의 D614G 변이를 가진 새로운 계보에 의해 발생했습니다. 이 계보는 이후 MIS-C가 처음 기술된 유럽과 미국에서 SARS-CoV-2 발병의 주된 원인이 될 것입니다.
{{ 키워드: }} 코로나19; D614G; MIS-C; 사스 코로나바이러스 2; 가성 뇌종양 증후군; 바이러스 혈통.