Abstract
Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b deposited on host cells. However, CD46 also plays roles in human reproduction, autophagy, modulating T cell activation and effector functions and is a member of the newly identified intracellular complement system (complosome). CD46 also is a receptor for 11 pathogens (‘pathogen magnet’). While CD46 deficiencies contribute to inflammatory disorders, its overexpression in cancers and role as a receptor for some adenoviruses has led to its targeting by oncolytic agents and adenoviral-based therapeutic vectors, including coronavirus disease of 2019 (COVID-19) vaccines. This review focuses on recent advances in identifying disease-causing CD46 variants and its pathogen connections.
【초록키워드】 COVID-19, coronavirus disease, complement system, Vaccines, Cancer, variant, complement, autophagy, Regulatory, Protein, T cell, pathogen, cancers, therapeutic, Pathogens, receptor, function, T cell activation, 2019, host cells, inflammatory disorders, cofactor, deficiency, Serine, serine protease, member, overexpression, vectors, while, CD46, contribute, expressed, cleave, C3b, disease-causing, modulating, 【제목키워드】 Protein, pathogen, deficiency, connection,