Abstract
The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.
Keywords: Coronavirus; Mutation; Neutralising antibody; SARS-CoV-2; Spike.
All Keywords
【저자키워드】 SARS-CoV-2, coronavirus, Mutation, spike, neutralising antibody, 【초록키워드】 Evolution, Europe, pandemic, Mutation, spike, SARS-CoV-2 pandemic, Sequencing, Infection, virus, molecular evolution, Spike protein, Clinical outcome, Asia, Spread, Characteristics, Host immune response, D614G variant, neutralising antibody, D614G, molecular, USA, Evidence, Point mutation, virus spread, effort, dominant, the spike protein, the SARS-CoV-2, 【제목키워드】 disease severity, Vaccine design, D614G mutation, viral infectivity, the SARS-CoV-2,
【저자키워드】 SARS-CoV-2, coronavirus, Mutation, spike, neutralising antibody, 【초록키워드】 Evolution, Europe, pandemic, Mutation, spike, SARS-CoV-2 pandemic, Sequencing, Infection, virus, molecular evolution, Spike protein, Clinical outcome, Asia, Spread, Characteristics, Host immune response, D614G variant, neutralising antibody, D614G, molecular, USA, Evidence, Point mutation, virus spread, effort, dominant, the spike protein, the SARS-CoV-2, 【제목키워드】 disease severity, Vaccine design, D614G mutation, viral infectivity, the SARS-CoV-2,
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SARS-CoV-2 대유행의 발달은 바이러스의 지리적 확산과 분자 진화를 특성화하기 위한 광범위한 전 세계 시퀀싱 노력을 촉발했습니다. 스파이크 단백질 D614G의 점돌연변이는 바이러스가 아시아에서 유럽과 미국으로 확산되면서 등장했으며 전 세계적으로 빠르게 지배적인 형태가 되었습니다. 여기에서 우리는 D614G 변이체가 어떻게 확인되었는지 검토하고 돌연변이가 바이러스의 특성, 감염의 임상 결과 및 숙주 면역 반응에 미치는 영향에 대한 최근 증거를 논의합니다.
{{ 키워드: }} 코로나바이러스; 돌연변이; 중화항체; 사스 코로나바이러스 2; 스파이크.