Abstract
Objective: There is an urgent need for effective treatments to prevent or attenuate lung and systemic inflammation, endotheliitis, and thrombosis related to COVID-19. This study aimed to assess the effectiveness of a multidrug-therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid (“TNR4” therapy) to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico.
Design and methods: A comparative effectiveness study was performed among 768 confirmed SARS-CoV-2 cases aged 18-80 years, who received ambulatory care at the Ministry of Health of Tlaxcala. A total of 481 cases received the TNR4 therapy, while 287 received another treatment (comparison group). All participants received home visits and/or phone calls for clinical evaluation during the 14 days after enrollment.
Results: Nearly 85% of cases who received the TNR4 recovered within 14 days compared to 59% in the comparison group. The likelihood of recovery within 14 days was 3.4 times greater among the TNR4 group than in the comparison group. Patients treated with TNR4 had a 75% and 81% lower risk of being hospitalized or death, respectively, than the comparison group.
Conclusions: TNR4 therapy improved recovery and prevented the risk of hospitalization and death among ambulatory COVID-19 cases.
Keywords: Acetylsalicylic acid; Azithromycin; COVID-19; Ivermectin; Mexico; Montelukast; SARS-CoV-2.
【저자키워드】 COVID-19, Ivermectin, SARS-CoV-2, Azithromycin, Mexico, Montelukast, Acetylsalicylic acid, 【초록키워드】 Ivermectin, Treatment, SARS-CoV-2, therapy, Hospitalized, Azithromycin, thrombosis, Hospitalization, lung, risk, Endotheliitis, clinical evaluation, Effectiveness, death, Montelukast, systemic inflammation, Care, Ambulatory care, COVID-19 cases, Acetylsalicylic acid, Enrollment, All participants, COVID-19 case, lower risk, Ministry of Health, Prevent, effective, likelihood, greater, was performed, treated, prevented, attenuate, All participant, 【제목키워드】 Ivermectin, therapy, Azithromycin, Hospitalization, death, Montelukast, Acetylsalicylic acid, COVID-19 case, Prevent,