Abstract
Arglabin (l(R),10(S)-epoxy-5(S),5(S),7(S)-guaia-3(4),ll(13)-dien-6,12-olide), is a natural sesquiterpene γ-lactone which was first isolated from Artemisia glabella. The compound has been shown to possess anti-inflammatory activity through inhibition of the NLR Family pyrin domain-containing 3 (NLRP3) inflammasome and production of proinflammatory cytokines including interleukin (IL)-1β and IL-18. A more hydrophilic derivative of the compound also exhibited antitumor activity in the breast, colon, ovarian, and lung cancer. Some other synthetic derivatives of the compound have also been synthesized with antitumor, cytotoxic, antibacterial, and antifungal activities. Since both NLRP3 inflammasome and cytokine storm are associated with the pathogenesis of COVID-19 and its lethality, compounds like arglabin might have therapeutic potential to attenuate the inflammasome-induced acute respiratory distress syndrome and/or the cytokine storm associated with COVID-19.
Keywords: Anti-inflammation; Arglabin; Artemisia; Asteraceae; COVID-19; Corona virus.
【저자키워드】 COVID-19, Anti-inflammation, Artemisia, Arglabin, Asteraceae, Corona virus., 【초록키워드】 Respiratory distress syndrome, Corona virus, Cytokine storm, Cytokines, Pathogenesis, acute respiratory distress syndrome, Anti-inflammation, lung cancer, anti-inflammatory activity, NLRP3 inflammasome, family, Breast, interleukin, Antibacterial, Inflammasome, proinflammatory cytokines, acute respiratory distress, NLRP3, NLR, respiratory distress, Sesquiterpene, Colon, Proinflammatory cytokine, Compound, therapeutic potential, syndrome, activities, pathogenesis of COVID-19, derivative, IL-18, cytotoxic, ovarian, epoxy, shown, exhibited, hydrophilic, attenuate, the cytokine storm, with COVID-19, 【제목키워드】 ARDS, with COVID-19,