Objective: To evaluate the value of MR liver extracellular volume (ECV_{liver}) in assessment of liver fibrosis with chronic hepatitis B (CHB), and to compare its performance with two-dimensional (2D) shear-wave elastography (SWE).
Materials and methods: A total of 68 CHB patients who were histologically diagnosed as fibrosis stages F0 to F4 were retrospectively analyzed. All patients underwent gadopentetate dimeglumine-enhanced T1-mapping and 2D SWE. ECV_{liver} and liver stiffness were measured and compared between fibrosis subgroups; their correlations with histologic findings were evaluated using Spearman correlation test and multiple regression analysis. Diagnostic performance in evaluating liver fibrosis stages was assessed and compared using receiver-operating characteristic analysis.
Results: Both ECV_{liver} and liver stiffness increased as the fibrosis score increased (F = 17.08 to 10.99, P < 0.001). ECV_{liver} displayed a strong correlation with fibrosis stage (r = 0.740, P < 0.001), and liver stiffness displayed a moderate correlation (r = 0.651, P < 0.001); multivariate analysis revealed that only ECV_{liver} was independently correlated with fibrosis stage (P < 0.001). Univariate analyses showed significant correlations of ECV_{liver} with fibrosis stage, inflammatory activity, and platelet count; among all, the fibrosis stage had the highest correlation coefficient and was the only independent factor (P < 0.001). Overall, ECV_{liver} had no significant different performance compared with 2D SWE for the identification of both fibrosis stage s ≥ F2 and F4 (P = 0.868 and 0.171).
Conclusion: MR ECV_{liver} plays a promising role in the prediction of liver fibrosis for patients with CHB, comparable to 2D SWE.
【저자키워드】 magnetic resonance imaging, cirrhosis, Liver fibrosis, Chronic Hepatitis B, extracellular space, Sonoelastography.,