Abstract
The duration of viral shedding of SARS-CoV-2 is usually less than 10 days. We experienced a COVID-19 case with prolonged viral shedding for 2 months. His cell mediated immunity has been depressed (CD4 + T cell <100/μl) due to advanced malignant lymphoma and chemotherapy which had been completed 4 months prior to the onset of symptoms of COVID-19. We administered several treatments against COVID-19, however the results of Polymerase Chain Reaction (PCR) from nasopharyngeal specimens remained positive to SARS-CoV-2 for 2 months. Moreover, virus isolation assays performed on Day 59 also remained positive. He was finally discharged on Day 69 with two consecutive negative PCR results for SARS-CoV-2. Immunocompromised status may prolong viral shedding and it is therefore important for the clinician to take into account this when assessing such patients.
Keywords: Bendamustine; Follicular lymphoma; Immunocompromised state; SARS-CoV-2 PCR; Viral replication.
【저자키워드】 viral replication, immunocompromised state, Bendamustine, Follicular lymphoma, SARS-CoV-2 PCR, 【초록키워드】 COVID-19, Treatment, SARS-CoV-2, viral shedding, CD4, Replication, Chemotherapy, polymerase chain reaction, T cell, Viral, PCR, virus isolation, viral replication, prolonged viral shedding, patients, Cell mediated immunity, Bendamustine, Follicular lymphoma, SARS-CoV-2 PCR, Chain Reaction, malignant lymphoma, clinician, reaction, COVID-19 case, chain, Negative PCR, symptoms of COVID-19, positive, nasopharyngeal specimen, Administered, immunocompromised status, performed, remained, Day, onset of symptom, less, discharged, 【제목키워드】 SARS-CoV-2, Immunocompromised patient, Prolonged,