Abstract
The 21st century has witnessed three outbreaks of coronavirus (CoVs) infections caused by severe acute respiratory syndrome (SARS)-CoV, Middle East respiratory syndrome (MERS)-CoV, and SARS-CoV-2. Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, spreads rapidly and since the discovery of the first COVID-19 infection in December 2019, has caused 1.2 million deaths worldwide and 226,777 deaths in the United States alone. The high amino acid similarity between SARS-CoV and SARS-CoV-2 viral proteins supports testing therapeutic molecules that were designed to treat SARS infections during the 2003 epidemic. In this review, we provide information on possible COVID-19 treatment strategies that act via inhibition of the two essential proteins of the virus, 3C-like protease (3CL pro ) or papain-like protease (PL pro ).
Keywords: 3 chymotrypsin-like cysteine protease; COVID-19; SARS coronavirus; SARS-CoV-2; coronavirus main protease; papain-like cysteine protease.
【저자키워드】 COVID-19, SARS-CoV-2, SARS Coronavirus, Coronavirus main protease, 3 chymotrypsin-like cysteine protease, papain-like cysteine protease., 【초록키워드】 coronavirus disease, Coronavirus disease 2019, coronavirus, SARS-CoV, Infection, Viral proteins, 3CL pro, protease, MERS, virus, Papain-like protease, Spread, Severe acute respiratory syndrome, Protein, Epidemic, COVID-19 infection, outbreak, death, United States, SARS Coronavirus, information, Amino acid, treatment strategy, Middle East respiratory syndrome, similarity, Middle East, cysteine, Support, acute respiratory syndrome, Therapeutic molecule, cysteine protease, syndrome, CoVs, chymotrypsin, Papain, treat, SARS infection, therapeutic molecules, SARS-CoV-2 viral, caused, the United State, 【제목키워드】 protease, therapeutic strategy, treat, targeting, SARS-CoV-2 viral,