Abstract
COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed.
Keywords: COVID-19; Gastrointestinal tract; Gut-lung axis; Inflammatory cytokine storm; Liver injury; Liver transplant.
【저자키워드】 COVID-19, gut-lung axis, Liver injury, gastrointestinal tract, liver transplant, Inflammatory cytokine storm, 【초록키워드】 SARS-CoV-2, ACE2, Cytokine storm, coronavirus, pandemic, gut-lung axis, cytokine, Symptom, severe acute respiratory syndrome Coronavirus, cough, abdominal pain, angiotensin-converting enzyme 2, Symptoms, SARS-CoV-2 receptor, Fever, Research, Gastrointestinal, Liver injury, receptor, respiratory, liver, mechanism, gastrointestinal tract, liver transplant, Angiotensin-converting enzyme, angiotensin, Inflammatory cytokine storm, respiratory symptoms, diarrhoea, digestive system, connection, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, enzyme, vomiting, aetiology, caused, include, reported, clinically, determine, expressed, suggested, digestive, reported symptom, the SARS-CoV-2, with COVID-19, 【제목키워드】 SARS-CoV-2, gastrointestinal tract, Effect, Potential,