Abstract
There are several reports that herpes zoster characterized by reactivation of varicella zoster virus (VZV) following coronavirus disease 2019 (COVID-19) vaccines can occur. Herein, we report VZV meningitis, herpes zoster ophthalmicus (HZO), and late neurotrophic keratitis after receiving a second dose of messenger RNA (mRNA) COVID-19 vaccine. A 74-year-old man developed a vesicular skin rash on the forehead, scalp, nose, and left upper eyelid with a severe headache. Five days earlier, he received a second dose of the BNT162b2 mRNA vaccine on his left arm. Ocular examination revealed conjunctival hyperemia and pseudodendrite in the peripheral cornea. VZV was detected in the cerebrospinal fluid using polymerase chain reaction. The patient was diagnosed with HZO and meningitis. The patient was treated with intravenous acyclovir and topical acyclovir ointment and levofloxacin 1.5% eye drops. One month later, he developed a central epithelial defect with a rolled margin, typical of a neurotrophic ulcer. Treatment with a therapeutic contact lens and a combination of topical recombinant human epithelial growth factor and ofloxacin ointment was initiated. At six months after vaccination, the slit-lamp examination findings were stable with a mild corneal superficial stromal haze.
Keywords: COVID-19 Vaccination; Herpes Zoster Ophthalmicus; Meningitis; Neurotropic Keratitis.
【저자키워드】 COVID-19 vaccination, Meningitis, Herpes Zoster Ophthalmicus, Neurotropic Keratitis., 【초록키워드】 COVID-19, coronavirus disease, Coronavirus disease 2019, Vaccine, COVID-19 vaccine, vaccination, headache, virus, BNT162b2, polymerase chain reaction, Reactivation, mRNA, therapeutic, Patient, Meningitis, Mild, levofloxacin, cerebrospinal fluid, acyclovir, epithelial, margin, BNT162b2 mRNA, BNT162b2 mRNA vaccine, Combination, Contact, Herpes Zoster Ophthalmicus, intravenous, ofloxacin, Chain Reaction, eye drops, contact lens, nose, herpes zoster, Messenger RNA, left arm, conjunctival hyperemia, second dose, growth factor, skin rash, varicella, ulcer, conjunctival, forehead, keratitis, hyperemia, Varicella zoster virus, Zoster, examination findings, Corneal, polymerase chain, haze, Neurotrophic keratitis, scalp, therapeutic contact lens, upper eyelid, diagnosed, receiving, characterized, treated, occur, initiated, examination finding, eyelid, Herpe, slit-lamp, 【제목키워드】 COVID-19, Herpes Zoster Ophthalmicus, report, Zoster, Herpe,