Abstract Background: Coronavirus disease 2019 (COVID-19) is an epidemic infectious disease resulted from 2019 novel coronavirus (2019-nCoV). Up till now, COVID-19 has swept globally. Currently, due to many high-profiled benefits, clinical studies on Toujie Quwen granule (TJQW) have been increasing. The aim of the study is to assess the efficacy and safety of TJQW used with conventional western therapy for COVID-19. Methods: Relevant randomized controlled trials (RCTs) were searched in Chinese and English databases, and the search time is January 2020 to May 2021. English databases include PubMed, Embase, Web of Science, and the Cochrane Library. Chinese databases include CNKI, WF, VIP, and CBM. The international clinical trial registration platform and the Chinese clinical trial registration platform of controlled trials will be searched by us from January 2020 to May 2021. According to the inclusion and exclusion criteria, screening literature, extraction data will be conducted by 2 researchers independently. Statistical analysis will be conducted using the RevMan 5.3.5 software. After screening the literature based on the inclusion and exclusion criteria, The Recommendation, Assessment, Development, and Evaluation (GRADE) system will be used to evaluate the quality of each result. Results: This study will provide the evidence for TJQW to be used with conventional western therapy for COVID-19. Conclusion: The efficacy and safety of TJQW used with conventional western therapy for COVID-19 will be assessed. INPLASY registration number: INPLASY202150038
【저자키워드】 Coronavirus disease 2019, protocol, systematic review, Toujie Quwen granule, 【초록키워드】 COVID-19, Randomized controlled trial, coronavirus disease, Coronavirus disease 2019, clinical trial, 2019-nCoV, Infectious disease, database, Novel coronavirus, 2019 novel coronavirus, Epidemic, controlled trials, International, Controlled trial, Clinical studies, Efficacy and safety, assessment, development, platform, RCTs, clinical study, Evidence, Analysis, statistical analysis, exclusion criteria, registration number, Web of Science, Chinese, Cochrane Library, inclusion and exclusion criteria, CNKI, researcher, Inclusion, English, include, conducted, searched, CBM, therapy for COVID-19, used to evaluate, VIP, 【제목키워드】 Meta-analysis, Coronavirus disease 2019, therapy,