Abstract
The role of angiotensin converting enzyme 2 has expanded from regulating the renin angiotensin system to regulating intestinal amino acid homeostasis and the gut microbiome. Recently, angiotensin converting enzyme 2 was identified as a primary receptor for severe acute respiratory syndrome coronaviruses 1 and 2 being expressed in multiple tissues including the luminal surface of the gut. In this brief perspective, we examine the role of angiotensin converting enzyme 2 as the receptor for severe acute respiratory syndrome coronavirus 2 and the impact of coronavirus disease 19 infection on the gut microbiome and on the gut epithelium.
Keywords: ACE2; Gut Microbiota; SAR-CoV-2.
All Keywords
【저자키워드】 ACE2, SAR-CoV-2, gut microbiota, 【초록키워드】 coronavirus disease, coronavirus, SAR-CoV-2, angiotensin converting enzyme 2, Infection, gut microbiome, severe acute respiratory syndrome Coronavirus, angiotensin converting enzyme, renin angiotensin system, Microbiome, gut microbiota, receptor, respiratory, homeostasis, Amino acid, angiotensin, Gut, acute respiratory syndrome, Renin, luminal, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, enzyme, Perspective, multiple tissues, intestinal, luminal surface, expressed, multiple tissue, 【제목키워드】 role,
【저자키워드】 ACE2, SAR-CoV-2, gut microbiota, 【초록키워드】 coronavirus disease, coronavirus, SAR-CoV-2, angiotensin converting enzyme 2, Infection, gut microbiome, severe acute respiratory syndrome Coronavirus, angiotensin converting enzyme, renin angiotensin system, Microbiome, gut microbiota, receptor, respiratory, homeostasis, Amino acid, angiotensin, Gut, acute respiratory syndrome, Renin, luminal, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, enzyme, Perspective, multiple tissues, intestinal, luminal surface, expressed, multiple tissue, 【제목키워드】 role,
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안지오텐신 전환 효소 2의 역할은 레닌 안지오텐신 시스템을 조절하는 것에서 장내 아미노산 항상성과 장내 미생물군유전체를 조절하는 것으로 확장되었습니다. 최근 안지오텐신 전환 효소 2는 장의 관강 표면을 비롯한 여러 조직에서 발현되는 중증 급성 호흡기 증후군 코로나바이러스 1 및 2에 대한 1차 수용체로 확인되었습니다. 이 간략한 관점에서 우리는 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 수용체로서의 지오텐신 전환 효소 2의 역할과 장내 미생물군집 및 장 상피에 대한 코로나바이러스 질병 19 감염의 영향을 조사합니다.
{{ 키워드: }} ACE2; 장내 미생물총; SAR-CoV-2.