Abstract
SARS Coronavirus-2 is one of the most widespread viruses globally during the 21 st century, whose severity and ability to cause severe pneumonia and death vary. We performed a comprehensive systematic review of all studies that met our standardised criteria and then extracted data on the age, symptoms, and different treatments of Covid-19 patients and the prognosis of this disease during follow-up. Cases in this study were divided according to severity and death status and meta-analysed separately using raw mean and single proportion methods. We included 171 complete studies including 62,909 confirmed cases of Covid-19, of which 148 studies were meta-analysed. Symptoms clearly emerged in an escalating manner from mild-moderate symptoms, pneumonia, severe-critical to the group of non-survivors. Hypertension (Pooled proportion (PP): 0.48 [95% Confident interval (CI): 0.35-0.61]), diabetes (PP: 0.23 [95% CI: 0.16-0.33]) and smoking (PP: 0.12 [95% CI: 0.03-0.38]) were highest regarding pre-infection comorbidities in the non-survivor group. While acute respiratory distress syndrome (PP: 0.49 [95% CI: 0.29-0.78]), (PP: 0.63 [95% CI: 0.34-0.97]) remained one of the most common complications in the severe and death group respectively. Bilateral ground-glass opacification (PP: 0.68 [95% CI: 0.59-0.75]) was the most visible radiological image. The mortality rates estimated (PP: 0.11 [95% CI: 0.06-0.19]), (PP: 0.03 [95% CI: 0.01-0.05]), and (PP: 0.01 [95% CI: 0-0.3]) in severe-critical, pneumonia and mild-moderate groups respectively. This study can serve as a high evidence guideline for different clinical presentations of Covid-19, graded from mild to severe, and for special forms like pneumonia and death groups.
Keywords: ARDS; Covid-19; SARS-CoV-2; critical; death; laboratory; mild; pneumonia; radiology; symptomatology.
【저자키워드】 COVID-19, SARS-CoV-2, ARDS, Pneumonia, Laboratory, radiology, death, Mild, Critical, symptomatology., 【초록키워드】 Treatment, Respiratory distress syndrome, ARDS, acute respiratory distress syndrome, Prognosis, severity, systematic review, Comorbidity, diabetes, smoking, virus, hypertension, Symptoms, Symptomatology, radiology, Patient, Complication, age, Follow-up, mortality rate, severe pneumonia, SARS Coronavirus, group, mortality rates, disease, COVID-19 patients, acute respiratory distress, Evidence, clinical presentation, criteria, respiratory distress, ground-glass opacification, confirmed case, Non-survivors, syndrome, death group, while, Complete, widespread, non-survivor, radiological, highest, performed, proportion, remained, form, groups, diabete, Bilateral, Confident, meta-analysed, 【제목키워드】 coronavirus disease, Meta-analysis, systematic review, clinical, Factor,