Abstract
Objectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic.
Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality.
Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800).
Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization.
Keywords: COVID-19; Coronavirus; HIV; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, HIV, coronavirus, 【초록키워드】 SARS-CoV-2, Corticosteroids, pandemic, Hospitalized, Comorbidities, outcome, CD4, Symptoms, clinical outcomes, cohort study, Laboratory, Clinical outcome, Cohort, Characteristics, Severity Score, Signs and symptoms, Antiretroviral therapy, Patient, Co-infection, Spain, Control, Laboratory parameters, COVID-19 hospitalization, multicentre, network, First wave, Admission, in-hospital mortality, HIV infection, retrospective, during admission, both groups, median age, statistically significant difference, PCR-confirmed COVID-19, Administered, Spanish, men, FIVE, Randomly, severity scores, selected, presenting, modify, age and sex, with HIV, in both group, individuals with COVID-19, number of comorbidities, patients hospitalized, the median, 【제목키워드】 Hospitalized, HIV-negative,