Discovery of Half-life of Circulating Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B Infection Using Heavy Water Labeling

Published on
Journal: Clinical Infectious Diseases: An Official Publicat
[저자] Rohit Loomba, Martin Decaris, Kelvin W Li, Mahalakshmi Shankaran, Hussein Mohammed, Marcy Matthews, Lisa M Richards, Phirum Nguyen, Emily Rizo, Barbara Andrews, Robin Soto, Thomas Angel, Vithika Suri, Kathryn M Kitrinos, Dwight Barnes, Gregg Czerwieniec, Kathy Brendza, G Mani Subramanian, Anuj Gaggar, Marc K Hellerstein
[Category] B형 간염,
Pubmed URL    [DOI] 10.1093/cid/ciy1100    
[Source] pubmed

In a pilot study, heavy water labeling was used to determine hepatitis B surface antigen (HBsAg) turnover rates in chronic hepatitis B (CHB) patients. The mean (standard deviation) half-life of HBsAg in blood was 6.7 (5.5) days, which reflects recent production in the liver and supports strategies aimed at reducing HBsAg production in CHB patients.

All Keywords
【저자키워드】 HBV, half-life, hepatitis B surface antigen, deuterated water,