Abstract
Objectives: This study was performed during the early outbreak period of coronavirus disease 2019 (COVID-19) and the seasonal epidemics of other respiratory viral infections, in order to describe the extent of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with other respiratory viruses. It also compared the diagnostic performances of upper respiratory tract (URT) and lower respiratory tract (LRT) samples for SARS-CoV-2 infection.
Methods: From 25 January to 29 March 2020, all URT and LRT samples collected from patients with suspected COVID-19 received in the virology laboratory of Pitié-Salpêtrière University Hospital (Paris, France) were simultaneously tested for SARS-CoV-2 and other respiratory viruses.
Results: A total of 1423 consecutive patients were tested: 677 (47.6%) males, 746 (52.4%) females, median age 50 (range, 1-103) years. Twenty-one (1.5%) patients were positive for both SARS-CoV-2 and other respiratory viruses. The detection rate of SARS-CoV-2 was significantly higher in LRT than in URT (53.6% vs. 13.4%; p<0.0001). The analysis of paired samples from 117 (8.2%) patients showed that SARS-CoV-2 load was lower in URT than in LRT samples in 65% of cases.
Conclusion: The detection of other respiratory viruses in patients during this epidemic period could not rule out SARS-CoV-2 co-infection. Furthermore, LRT samples increased the accuracy of diagnosis of COVID-19.
Keywords: Co-infection; Lower respiratory tract; Other respiratory viruses; SARS-CoV-2.
【저자키워드】 SARS-CoV-2, Co-infection, Lower respiratory tract, Other respiratory viruses, 【초록키워드】 COVID-19, coronavirus disease, viruses, SARS-CoV-2, Coronavirus disease 2019, coronavirus, SARS-COV-2 infection, Epidemics, diagnostic, severe acute respiratory syndrome Coronavirus, Laboratory, respiratory viruses, Epidemic, Viral, Accuracy, outbreak, Patient, Co-infection, France, respiratory, URT, university, Other, upper respiratory tract, detection rate, respiratory viral infections, Analysis, Lower respiratory tract, Other respiratory viruses, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, median age, Paris, positive, Lower, females, males, tested, collected, was performed, significantly higher, other respiratory virus, consecutive patient, diagnosis of COVID-19, LRT, 【제목키워드】 SARS-CoV-2, other respiratory virus, diagnosis of COVID-19,