Abstract
Scope: The objective of these guidelines is to identify the most appropriate diagnostic test and/or diagnostic approach for SARS-CoV-2. The recommendations are intended to provide guidance to clinicians, clinical microbiologists, other health care personnel, and decision makers.
Methods: An ESCMID COVID-19 guidelines task force was established by the ESCMID Executive Committee. A small group was established, half appointed by the chair and the remaining selected with an open call. Each panel met virtually once a week. For all decisions, a simple majority vote was used. A list of clinical questions using the PICO (population, intervention, comparison, outcome) format was developed at the beginning of the process. For each PICO, two panel members performed a literature search focusing on systematic reviews, with a third panellist involved in case of inconsistent results. Quality of evidence assessment was based on the GRADE-ADOLOPMENT (Grading of Recommendations Assessment, Development and Evaluation – adoption, adaptation, and de novo development of recommendations) approach.
Recommendations: A total of 43 PICO questions were selected that involve the following types of populations: (a) patients with signs and symptoms of COVID-19; (b) travellers, healthcare workers, and other individuals at risk for exposure to SARS-CoV-2; (c) asymptomatic individuals, and (d) close contacts of patients infected with SARS-CoV-2. The type of diagnostic test (commercial rapid nucleic acid amplification tests and rapid antigen detection), biomaterial, time since onset of symptoms/contact with an infectious case, age, disease severity, and risk of developing severe disease are also taken into consideration.
Keywords: COVID-19; Diagnosis; Guidelines; SARS-CoV-2; Testing.
【저자키워드】 COVID-19, SARS-CoV-2, Diagnosis, guidelines, testing., 【초록키워드】 Health care, Healthcare workers, disease severity, diagnostic test, diagnostic, risk, Intervention, Symptom, outcome, nucleic acid, Health, Testing, Asymptomatic individuals, healthcare, Signs and symptoms, Patient, age, adaptation, Quality, nucleic acid amplification, assessment, development, antigen detection, Care, Guidance, recommendations, Evidence, close contact, severe disease, systematic reviews, exposure to, once a week, Task Force, Clinicians, individual, list, de novo, PICO, recommendation, approach, Committee, chair, selected, identify, performed, was used, involved, majority, question, COVID-19 guideline, infected with SARS-CoV-2, 【제목키워드】 diagnostic,