Abstract Objectives To investigate laboratory markers for COVID‐19 progression in patients with different medical conditions. Methods We performed a multicenter retrospective study of 836 cases in Hubei. To avoid the collinearity among the indicators, principal component analysis (PCA) followed by partial least squares discriminant analysis (PLS‐DA) was performed to obtain an overview of laboratory assessments. Multivariable logistic regression analysis and multivariable Cox proportional hazards regression analysis were respectively used to explore risk factors associated with disease severity and mortality. Survival analysis was performed in patients with the most common comorbidities. Results Lactate dehydrogenase (LDH) and prealbumin were associated with disease severity in patients with or without comorbidities, indicated by both PCA/PLS‐DA and multivariable logistic regression analysis. The mortality risk was associated with age, LDH, C‐reactive protein (CRP), D‐dimer, and lymphopenia in patients with comorbidities. CRP was a risk factor associated with short‐term mortality in patients with hypertension, but not liver diseases; additionally, D‐dimer was a risk factor for death in patients with liver diseases. Conclusions Lactate dehydrogenase was a reliable predictor associated with COVID‐19 severity and mortality in patients with different medical conditions. Laboratory biomarkers for mortality risk were not identical in patients with comorbidities, suggesting multiple pathophysiological mechanisms following COVID‐19 infection. Lactate dehydrogenase was a reliable predictor associated with COVID‐19 severity and mortality. Mortality risk factors were not identical in COVID‐19 patients with comorbidities. CRP was related with death risk in patients with hypertension, but not liver diseases. D‐dimer was an independent risk factor for death in patients with liver diseases.
【저자키워드】 diabetes, Coronavirus disease‐19 (COVID‐19), hypertension, lactate dehydrogenase, liver diseases, 【초록키워드】 Biomarker, Risk factors, Mortality, severity, disease severity, Comorbidities, LDH, risk, CRP, progression, risk factor, hypertension, lactate dehydrogenase, liver diseases, principal component analysis, Laboratory, COVID‐19, lymphopenia, Retrospective study, Patient, death, age, laboratory biomarkers, multicenter, liver, marker, Lactate, mortality risk, Analysis, survival analysis, PCA, D‐dimer, Medical conditions, followed by, Principal component, discriminant analysis, regression analysis, Logistic regression analysis, assessments, COVID‐19 patients, multivariable logistic regression, prealbumin, pathophysiological mechanism, mortality risk factors, independent risk factor, C‐reactive protein, collinearity, COVID‐19 infection, Multivariable logistic regression analysis, objective, multivariable, Result, performed, indicated, was performed, COVID‐19 patient, Cox proportional hazard, partial least square, patients with comorbidities, was related, 【제목키워드】 progression, COVID‐19, Retrospective study, Patient, marker,