Abstract
To evaluate the use of asymptomatic surveillance, we implemented a surveillance program for asymptomatic SARS-CoV-2 infection in a voluntary sample of individuals at the College of Veterinary Medicine at the University of Minnesota. Self-collected anterior nasal samples were tested using real time reverse transcription-polymerase chain reaction (RT-PCR), in a 5:1 pooled testing strategy, twice weekly for 18 weeks. Positive pools were deconvoluted into individual tests, revealing an observed prevalence of 0.07% (3/4,525). Pooled testing allowed for large scale testing with an estimated cost savings of 79.3% and modeling demonstrated this testing strategy prevented up to 2 workplace transmission events, averting up to 4 clinical cases. At the study endpoint, antibody testing revealed 80.7% of participants had detectable vaccine antibody levels while 9.6% of participants had detectable antibodies to natural infection.
Keywords: COVID-19; SARS-CoV-2; cost effective; pooled testing; serology; surveillance; veterinary medicine.
【저자키워드】 COVID-19, SARS-CoV-2, serology, Surveillance, pooled testing, cost effective, veterinary medicine., 【초록키워드】 Vaccine, Antibody testing, serology, antibody, SARS-COV-2 infection, Transmission, RT-PCR, Medicine, Prevalence, Asymptomatic, modeling, natural infection, university, Reverse transcription-polymerase chain reaction, real time, Nasal sample, Chain Reaction, veterinary medicine, Endpoint, twice weekly, individual, participant, college, tested, evaluate, detectable, events, demonstrated, prevented, 【제목키워드】 Asymptomatic, university, Teaching, surveillance testing,