ABSTRACT We performed an annotation of 35 mutations in the spike protein of the SARS-CoV-2 Omicron variant. Our analysis of the mutations indicates that Omicron has gained prominent immune evasion and potential for enhanced transmissibility. Previous modeling study has revealed that continued evolution in both immune evasion and enhanced transmissibility by SARS-CoV-2 would compromise vaccines as tools for the pandemic control. To combat the future variants of SARS-CoV-2, the world needs novel antiviral drugs that are effective at curb viral spreading without introducing additional selective pressure towards resistant variants.
All Keywords
【저자키워드】 SARS-CoV-2, COVID19, Omicron variants, COVID19vaccines, COVID19drugs, 【초록키워드】 Evolution, Vaccine, pandemic, Mutation, antiviral drugs, variant, omicron, variants, Spike protein, immune evasion, Viral, Transmissibility, Analysis, CURB, novel antiviral drugs, annotation, selective, variants of SARS-CoV-2, effective, performed, indicate, the spike protein, novel antiviral drug, the SARS-CoV-2, 【제목키워드】 Perspective,
【저자키워드】 SARS-CoV-2, COVID19, Omicron variants, COVID19vaccines, COVID19drugs, 【초록키워드】 Evolution, Vaccine, pandemic, Mutation, antiviral drugs, variant, omicron, variants, Spike protein, immune evasion, Viral, Transmissibility, Analysis, CURB, novel antiviral drugs, annotation, selective, variants of SARS-CoV-2, effective, performed, indicate, the spike protein, novel antiviral drug, the SARS-CoV-2, 【제목키워드】 Perspective,
초록 우리는 SARS-CoV-2 Omicron 변이체의 스파이크 단백질에서 35개의 돌연변이에 대한 주석을 수행했습니다. 돌연변이에 대한 우리의 분석은 Omicron이 현저한 면역 회피와 향상된 전염 가능성을 얻었음을 나타냅니다. 이전의 모델링 연구에서는 SARS-CoV-2에 의한 면역 회피와 향상된 전염성 모두의 지속적인 진화가 전염병 통제를 위한 도구로서의 백신을 손상시킬 것이라고 밝혔습니다. SARS-CoV-2의 미래 변종과 싸우기 위해 세계는 내성 변이에 대한 추가적인 선택 압력을 가하지 않고 바이러스 확산을 억제하는 데 효과적인 새로운 항바이러스제가 필요합니다.