Abstract
Background: Scarce and non-homogeneous data are available on the prognostic value of clinic heart rate (HR) in coronavirus disease 2019 (COVID-19).
Methods: The present study evaluated in 389 patients hospitalized for COVID-19 the in-hospital prognostic value of resting HR, assessed over different time periods, i.e., at hospital admission, during initial 3 days and 7 days of hospitalization.
Results: Results show that assessment of this hemodynamic variable during hospitalization provides information on the clinical outcome of the patients, greater HR values being associated with a worse inhospital prognosis. The prognostic value of elevated HR during COVID-19: 1) was independent on other confounders such as age, gender, comorbidities and fever, 2) appeared to be strengthened by repeated measurements of HR during the initial 3/7 days of hospitalization, and 3) was detectable in patients in which the therapeutic intervention did not include drugs, such as beta-blockers, calcium antagonists, digoxin, ivabradine and antiarrhythmic compounds known to interfere with HR.
Conclusions: Heart rate may represent an important marker of a patient’s outcome in COVID-19.
Keywords: coronavirus disease 2019 (COVID-19); heart rate; prognosis; sympathetic nervous system.
【저자키워드】 Prognosis, Coronavirus disease 2019 (COVID-19), heart rate, sympathetic nervous system., 【초록키워드】 COVID-19, coronavirus disease, Coronavirus disease 2019, Prognosis, Hospitalization, Comorbidities, drugs, Comorbidity, Gender, outcome, Clinical outcome, Fever, Patient, nervous system, age, Hospital admission, heart rate, information, patients, calcium, marker, hemodynamic, In-hospital, Prognostic value, Compound, therapeutic intervention, antagonists, repeated, confounder, digoxin, independent, initial, ivabradine, Result, greater, include, detectable, evaluated, elevated, provide, interfere, patients hospitalized, 【제목키워드】 COVID-19, Prognostic marker, heart rate, In-hospital, independent,