Abstract
Purpose: The capability of lung ultrasound (LUS) to distinguish the different pulmonary patterns of COVID-19 and quantify the disease burden compared to chest CT is still unclear.
Methods: PCR-confirmed COVID-19 patients who underwent both LUS and chest CT at the Emergency Department were retrospectively analysed. In both modalities, twelve peripheral lung zones were identified and given a Severity Score basing on main lesion pattern. On CT scans the well-aerated lung volume (%WALV) was visually estimated. Per-patient and per-zone assessments of LUS classification performance taking CT findings as reference were performed, further revisioning the images in case of discordant results. Correlations between number of disease-positive lung zones, Severity Score and %WALV on both LUS and CT were assessed. The area under receiver operating characteristic curve (AUC) was calculated to determine LUS performance in detecting %WALV ≤ 70 %.
Results: The study included 219 COVID-19 patients with abnormal chest CT. LUS correctly identified as positive 217 (99 %) patients, but per-zone analysis showed sensitivity = 75 % and specificity = 66 %. The revision of the 121 (55 %) cases with positive LUS and negative CT revealed COVID-compatible lesions in 42 (38 %) CT scans. Number of disease-positive zones, Severity Score and %WALV between LUS and CT showed moderate correlations. The AUCs for LUS Severity Score and number of LUS-positive zones did not differ in detecting %WALV ≤ 70 %.
Conclusion: LUS in COVID-19 is valuable for case identification but shows only moderate correlation with CT findings as for lesion patterns and severity quantification. The number of disease-positive lung zones in LUS alone was sufficient to discriminate relevant disease burden.
Keywords: COVID-19; Diagnostic techniques and procedures; Lung; Tomography; Ultrasonography; X-Ray computed.
【저자키워드】 COVID-19, lung, tomography, diagnostic techniques and procedures, Ultrasonography, X-Ray computed., 【초록키워드】 severity, lung, tomography, emergency department, X-ray, sensitivity, specificity, Severity Score, Chest CT, CT scan, Patient, CT scans, correlation, assessment, characteristic, quantification, disease, moderate, patients, score, Analysis, Emergency, COVID-19 patient, Ultrasonography, AUC, receiver operating characteristic, lesion, Volume, number, CT findings, receiver operating characteristic curve, correlations, PCR-confirmed COVID-19, zone, Department, positive, revision, not differ, performed, the disease, analysed, calculated, determine, CT finding, were assessed, 【제목키워드】 COVID-19 patient,