Abstract
Background: SARS-CoV-2 infected patients present thrombotic complications caused by direct endothelial cells injury of the microvessels. Pulmonary thromboembolism (PE) has been reported by Computed Tomography pulmonary angiogram (CTPA) in patients with COVID-19 pneumonia with high D-dimer levels.
Objectives: We present the characteristics of SARS-CoV-2 infected patients diagnosed of PE by CTPA in our hospital. We also present the comparison of these findings with non-infected patients with PE data.
Methods: Retrospective observational cohort study that included patients over 18 years of age hospitalised consecutively between 26th February and 20th May 2020 in an European Hospital with SARS-CoV2 virus infection, and with suspected infection at beginning of admission but with negative PCR, who were studied with CTPA for suspicion of VTE, during their hospitalization.
Results: During the study period, 52 CTPA were performed in our hospital, sixteen in SARS-CoV-2 infected patients, with 4 cases (33%) of PE in the infected group, and 11 (44%) in the non-infected group. No significant differences in age (p = 0.43) and sex (p = 0.31) were found between the two groups, infected and non-infected patients. In the infected group, the patients who had PE had a much lower median age (47.8 years) than those without PE (73.3 years). No differences between infected and non-infected patients were detected in the diagnosis of PE with CTPA, 28.6% versus 27.8% (p = 1.00). Overall patient mortality was 1.9%; one patient died (6.3%) in the infected group, and none in the non-infected group (p = 0.31).
Conclusion: A considerable incidence of PE diagnosed by CTPA in SARS-CoV-2 infected patients has been observed, despite thrombo-prophylaxis.
Keywords: COVID-19; Coagulation; Coronavirus; SARS-CoV-2; Thromboembolism; Thrombosis.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, Coagulation, Thromboembolism, thrombosis., 【초록키워드】 COVID-19 pneumonia, SARS-CoV2, thrombosis, Hospitalization, Pneumonia, Thrombotic complications, hospital, Infection, Diagnosis, Sex, Computed tomography, Characteristics, endothelial cells, Patient, Thromboembolism, age, virus infection, incidence, Admission, patients, Pulmonary thromboembolism, Endothelial cell, Injury, VTE, CTPA, Observational cohort study, significant difference, no significant differences, two groups, D-dimer levels, SARS-CoV-2 infected patients, median age, one patient, study period, no differences, thrombotic, Negative PCR, suspicion, retrospective observational cohort study, patient mortality, hospitalised, European, thrombotic complication, non-infected, performed, caused, died, reported, the patient, diagnosed, infected patient, much lower, patients with COVID-19, patients with PE, SARS-CoV-2 infected patient, those without PE, 【제목키워드】 Hospitalized, incidence, SARS-CoV-2 infected patient,