Abstract
The purpose of this study was to assess the clinical performance of STANDARD F COVID-19 Ag FIA (SD Biosensor Inc., Gyeonggi-do, Republic of Korea), a rapid antigen detection test (RADT) for diagnosing SARS-CoV-2, in patients attended at the Emergency Department with signs or symptoms compatible with COVID-19 that had started in the last 5 days. The clinical performance of the antigen test was compared with RT-PCR, the reference standard. We included 663 specimens from non-repetitive patients. Clinical sensitivity and specificity were 84.0% (95% CI 76.1-89.7) and 99.6% (95% CI 98.5-99.9), respectively. The positive and negative predictive values were 98.1% (95% CI 92.7-99.7) and 96.4% (95% CI 94.4-97.7), respectively. The kappa index agreement between RT-PCR and the RADT was 0.89 (95% CI 0.84-0.93). We concluded that STANDARD F COVID-19 Ag FIA is an excellent first-line RADT method to diagnose symptomatic patients in the emergency department.
Keywords: COVID-19; Emergency Department; Rapid antigen test; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, emergency department, rapid antigen test, 【초록키워드】 SARS-CoV-2, Symptom, RT-PCR, emergency department, Antigen, Symptomatic patients, Sensitivity and specificity, clinical, Patient, Rapid, antigen detection, patients, reference standard, diagnose, Emergency, Negative predictive value, clinical sensitivity, 95% CI, specimen, Department, diagnosing, positive, SD Biosensor, Inc., symptomatic patient, with COVID-19, 【제목키워드】 antigen detection, Emergency, Department, diagnosing,