Abstract
Introduction: In this study, it is planned to compare the real-time reverse transcription-polymerase chain reaction (RT-PCR) test, which is the gold standard in the diagnosis of COVID-19, with thorax computed tomography (CT) and rapid antibody test results.
Methods: Patients who were admitted to the emergency service of İzmir Çiğli Training and Research Hospital between 01.04.2020 and 31.05.2020 and who were suspected of having COVID-19 infection were included in the study. The medical records of the patients were retrospectively analysed through the hospital data processing database. Age, gender, hospitalisation, status of home quarantine, real-time RT-PCR, thorax CT and rapid antibody test results of the patients were examined. The relationship between RT-PCR, thorax CT and rapid antibody test results was compared statistically.
Results: A total of 181 patients, 115 (63.5%) male and 66 (36.5%) female, with an average age of 56.4 ± 18.06 years were included in the study. The nasopharyngeal swab PCR result obtained at the first admission of the patients to the emergency department was positive in 71 (39.2%) patients. Rapid antibody tests performed at hospital admission were positive in 57 (31.5%) patients. Thorax CT was performed in 173 (95.6%) patients who applied to the emergency department, and 112 (64.7%) of them had findings that could be compatible with COVID-19. According to the thorax CT findings in patients, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for detecting COVID-19 infection were, respectively, 76.1%, 43.1%, 48.2% and 72.1% (ĸ: 0.176, P < .001). According to the rapid antibody test results, sensitivity, specificity, PPV and NPV for detecting COVID-19 infection were 57.5%, 85.5%, 71.9% and 75.8%, respectively (ĸ: 0.448, P < .001). In our study, the mortality rate for COVID-19 was found to be 2.8%.
Conclusion: Rapid antibody test and thorax CT examinations were found to have low diagnostic value in patients who admitted to the emergency department of our hospital and whose first RT-PCR SARS-CoV-2 test was positive. Studies involving larger patient groups are needed for their use alone in diagnosis and screening.
【초록키워드】 COVID-19, rapid antibody test, hospital, Diagnosis, Gender, RT-PCR, database, emergency department, Predictive value, Computed tomography, Nasopharyngeal swab, polymerase chain reaction, sensitivity, specificity, Positive predictive value, COVID-19 infection, antibody tests, Data processing, male, female, Patient, Rapid, gold, age, Hospital admission, Antibody test, mortality rate, real-time RT-PCR, hospitalisation, Admission, patients, home quarantine, Negative predictive value, emergency service, average age, medical records, Chain Reaction, medical record, training, Thorax, gold standard, diagnostic value, average, real-time reverse transcription-polymerase chain reaction, positive, SARS-CoV-2 test, nasopharyngeal swab PCR, performed, examined, the patient, patient group, applied, was performed, analysed, statistically, CT finding, diagnosis of COVID-19, NPV, PPV, with COVID-19, 【제목키워드】 COVID-19, Patient, Thorax, pre-diagnosis,