Abstract
Based on computerized modeling studies, it has been postulated that the severe hypoxemia in COVID-19 may result from impaired oxygen carrying capacity on hemoglobin. Standard pulse oximetry may not detect hypoxemia resulting from hemoglobinopathy, therefore hemoglobin co-oximetry is needed to evaluate this divergence. In a clinical data analysis of a multicenter cohort of hospitalized patients with COVID-19, we found a minimal effect, less than 1%, on the correlation between oxyhemoglobin concentration and predicted oxygen saturation in the presence of COVID-19 infection. This effect is unlikely to explain the clinically significant hypoxia in COVID-19 patients.
Keywords: COVID-19; Hemoglobinopathy; Hypoxia; Respiratory failure.
【저자키워드】 COVID-19, Respiratory failure, hypoxia, Hemoglobinopathy, 【초록키워드】 Respiratory failure, hypoxia, pulse oximetry, oxygen, hospitalized patients, oxygen saturation, Cohort, COVID-19 infection, Hypoxemia, hemoglobin, multicenter, respiratory, correlation, COVID-19 patients, Concentration, Analysis, Hemoglobinopathy, Standard, Carrying Capacity, oximetry, Clinical data, severe hypoxemia, oxyhemoglobin, resulting, predicted, detect, evaluate, clinically, unlikely, less, hospitalized patient, explain, with COVID-19, 【제목키워드】 Concentration, Support,