Background We investigated if the concentration and “rangeability” of cystatin C (CysC) influenced the prognosis of coronavirus disease 2019 (COVID-19) in patients suffering from, or not suffering from, type 2 diabetes mellitus (T2DM). Methods A total of 675 T2DM patients and 572 non-T2DM patients were divided into “low” and “high” CysC groups and low and high CysC-rangeability groups according to serum CysC level and range of change of CysC level, respectively. Demographic characteristics, clinical data, and laboratory results of the four groups were analyzed. Results COVID-19 patients with a high level and rangeability of CysC had more organ damage and a higher risk of death compared with those with a low level or low rangeability of CysC. Patients with a higher level and rangeability of CysC had more blood lymphocytes and higher levels of C-reactive protein, alanine aminotransferase, and aspartate aminotransferase. After adjustment for possible confounders, multivariate analysis revealed that CysC >0.93 mg/dL was significantly associated with the risk of heart failure (OR = 2.231, 95% CI: 1.125–5.312) and all-cause death (2.694, 1.161–6.252). CysC rangeability >0 was significantly associated with all-cause death (OR = 4.217, 95% CI: 1.953–9.106). These associations were stronger in patients suffering from T2DM than in those not suffering from T2DM. Conclusions The level and rangeability of CysC may influence the prognosis of COVID-19. Special care and appropriate intervention should be undertaken in COVID-19 patients with an increased CysC level during hospitalization and follow-up, especially for those with T2DM.
【저자키워드】 COVID-19, Type 2 diabetes mellitus, cystatin C, renal function, all-cause death, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Lymphocytes, Prognosis, Hospitalization, Diabetes Mellitus, Type 2 diabetes mellitus, C-reactive protein, risk, Intervention, diabetes, cystatin C, heart failure, serum, Characteristics, Laboratory results, Patient, death, Aspartate aminotransferase, Follow-up, group, demographic, Care, COVID-19 patients, association, Multivariate analysis, Concentration, Analysis, COVID-19 patient, demographic characteristics, alanine aminotransferase, higher risk, 95% CI, Clinical data, aspartate, confounders, Alanine, four groups, organ damage, Result, analyzed, significantly, investigated, blood lymphocyte, four group, had more, laboratory result, type 2 diabete, 【제목키워드】 cystatin C, Type,