Abstract
A 72-year-old patient was admitted to the intensive care unit due to acute respiratory distress syndrome caused by COVID-19. On day 20, the patient experienced shock. The electrocardiogram showed ST segment elevation in leads V3-V6 and severe left ventricular dysfunction with an ejection fraction of 35%-40%. The left ventricle showed basal hypokinesis and apical akinesis, while the creatine kinase level was normal, indicating Takotsubo cardiomyopathy. On day 24, the patient died of multiple organ failure. In post-mortem biopsy, SARS-CoV-2 antigen was detected in cardiomyocytes by immunostaining. Moreover, SARS-CoV-2 RNA was detected in heart tissue. We need to further analyse the direct link between SARS-CoV-2 and cardiomyocytes.
Keywords: SARS-CoV-2; cardiomyocyte; co-localization; immunostaining.
【저자키워드】 SARS-CoV-2, cardiomyocyte, co-localization, immunostaining., 【초록키워드】 COVID-19, Respiratory distress syndrome, intensive care, acute respiratory distress syndrome, creatine, intensive care unit, electrocardiogram, Shock, Patient, Takotsubo cardiomyopathy, SARS-CoV-2 RNA, creatine kinase, SARS-CoV-2 antigen, multiple organ failure, Localization, acute respiratory distress, immunostaining, Organ failure, respiratory distress, left ventricular dysfunction, Ejection fraction, left ventricle, syndrome, ventricular dysfunction, heart tissue, post-mortem biopsy, caused, died, the patient,