Abstract
Background and purpose: This case illustrates for the first time the clinical and radiological evolution of SARS-CoV-2 meningo-encephalitis.
Methods: A case of a SARS-CoV-2 meningo-encephalitis is reported.
Results: A 65-year-old man with COVID-19 presenting with meningo-encephalitis without respiratory involvement is described. He had fever, diarrhea and vomiting, followed by diplopia, urinary retention and sleepiness. Examination disclosed a convergence strabismus and ataxia. Cerebrospinal fluid (CSF) showed lymphocytic pleocytosis, oligoclonal bands and increased interleukin 6 level. SARS-CoV-2 was detected in the CSF through reverse transcriptase polymerase chain reaction, but not in nasopharyngeal, tracheal secretion and rectal samples. Brain magnetic resonance imaging showed lesions on white matter hemispheres, the body and splenium of the corpus callosum and resembling the projection of corticospinal tract, remarkably on cerebellar peduncles.
Conclusions: This demonstrates the challenges in diagnosing COVID-19 in patients with neurological presentations.
Keywords: COVID-19; SARS-CoV-2; diagnosis; meningo-encephalitis; polymerase chain reaction.
【저자키워드】 COVID-19, SARS-CoV-2, Diagnosis, polymerase chain reaction., meningo-encephalitis, 【초록키워드】 magnetic resonance imaging, diarrhea, Encephalitis, interleukin 6, polymerase chain reaction, Reverse transcriptase polymerase chain reaction, nasopharyngeal, Fever, Evolution of SARS-CoV-2, cerebrospinal fluid, CSF, Diplopia, neurological, Ataxia, Corpus callosum, followed by, reverse transcriptase, Chain Reaction, lesion, White matter, urinary retention, examination, projection, lesions, secretion, vomiting, diagnosing, transcriptase, sleepiness, corpus, rectal, radiological, pleocytosis, polymerase chain, corticospinal tract, splenium, strabismus, described, reported, tracheal, presenting, callosum, corticospinal, COVID-19 in patient, with COVID-19, 【제목키워드】 coronavirus, clinical, acute respiratory syndrome, radiological feature,