The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe global public health emergency. However, there are no sensitive biomarkers to predict the disease prognosis of COVID-19 patients. Here, we have identified interleukin-8 (IL-8) as a biomarker candidate to predict different disease severity and prognosis of COVID-19 patients. While serum IL-6 become obviously elevated in severe COVID-19 patients, serum IL-8 was easily detectible in COVID-19 patients with mild syndromes. Furthermore, lL-8 levels correlated better than IL-6 levels with the overall clinical disease scores at different stages of the same COVID-19 patients. Thus, our studies suggest that IL-6 and IL-8 can be respectively used as biomarkers for severe COVID-19 patients and for COVID-19 disease prognosis.
【저자키워드】 Cytokine storm, Biomarker, interleukin-8, interleukin-6, cytokine serum profile, coronavirus disease-2019 prognosis, respiratory syndrome coronavirus 2, 【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, coronavirus, Biomarkers, Prognosis, IL-6, disease severity, Infection, interleukin-8, respiratory syndrome coronavirus 2, COVID-19 disease, Prevalence, serum, interleukin, IL-8, Mild, respiratory, predict, COVID-19 patients, COVID-19 patient, IL-6 levels, Serum IL-6, global public health, severe COVID-19 patients, Stage, severe respiratory syndrome, respiratory syndrome coronavirus, clinical disease, while, widespread, caused, the disease, elevated, correlated, IL-6 level, severe COVID-19 patient, 【제목키워드】 coronavirus, coronavirus disease-2019,