The discovery of respiratory tract involvement in the pathogenesis of foot-and-mouth disease (FMD) and the recognition of the role of inhalated aerosols in virus transfer opened new outlooks in the epizootology and prophylaxis of the disease. Nevertheless, FMD should be regarded for an infection transmitted by contaminated passive vectors including man and stable equipment. Transient persistence of FMD virus in the upper respiratory airways of cattle is of interest, but there is no reason to consider this for a significant hazard. Regular annual immunization with a vaccine containing the most isolated virus serotypes seems to be the best way how to prevent epizootics and panzootics.
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