Abstract
Background: Neonatal transmission of SARS-CoV-2 from positive mothers to their babies has been a real concern, opening the arena of research in this area.
Objective: To detect the possibility of vertical transmission of SARS-CoV-2 from COVID-19-positive mothers to their neonates and the clinicopathological outcome in them.
Design: A single-centre, prospective, observational study involving 47 COVID-19-positive mothers and their neonates.
Setting: A tertiary care hospital in Eastern India.
Participants: Neonates born to SARS-CoV-2-infected mothers.
Main outcome measures: We investigated the SARS-CoV-2 positivity rate by real-time reverse transcriptase-PCR (RT-PCR) done twice (on admission and after 24 hours of admission) in neonates born to SARS-CoV-2-positive mothers, who tested RT-PCR positive for this virus in their nasopharyngeal swab. Clinical outcome was also assessed in these neonates during their hospital stay.
Results: Out of 47 neonates born to SARS-CoV-2-positive mothers, four were SARS-CoV-2 positive by RT-PCR. All the neonates in our study were discharged home in stable condition after management of acute complications. None of them required readmission.
Conclusion: Vertical transmission occurs in neonates born to COVID-19-positive mothers; however, the risk is small. Majority of the neonates remain asymptomatic with good clinical outcome.
Keywords: neonatology.
【저자키워드】 neonatology, 【초록키워드】 SARS-CoV-2, hospital, India, neonatology, risk, outcome, RT-PCR, virus, observational study, Clinical outcome, Nasopharyngeal swab, Neonate, Neonates, Asymptomatic, clinical, management, Research, complications, vertical transmission, Admission, Care, mother, readmission, Hospital stay, reverse transcriptase, 24 hours, positive, transmission of SARS-CoV-2, discharged home, arena, SARS-CoV-2-positive mothers, tested, detect, investigated, required, occur, 24 hour, the SARS-CoV-2, 【제목키워드】 Neonate, Care,