Abstract
We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 43 days after the disease onset. The autopsy revealed prominent organization of alveoli and alveolar ducts, with a massive accumulation of macrophages in the lungs. A few severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen-positive cells were detected in the lung, suggesting delayed virus clearance owing to his long-term immunosuppressed state, leading to constant lung damage and ultimately respiratory failure.
Keywords: COVID-19; Coronavirus disease 2019; SARS-CoV-2; immunosuppressed; kidney transplant.
【저자키워드】 COVID-19, SARS-CoV-2, Coronavirus disease 2019, kidney transplant, Immunosuppressed, 【초록키워드】 coronavirus disease, Macrophage, Coronavirus disease 2019, coronavirus, Azithromycin, Respiratory failure, macrophages, Hydroxychloroquine, mechanical ventilation, lung, Autopsy, Antigen, Lungs, Patient, disease, kidney transplant, alveoli, Immunosuppressed, disease onset, lung damage, respiratory status, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, virus clearance, positive cells, alveolar, Cell, died, the disease, treated, 【제목키워드】 Transplant, respiratory,