Summary Non-steroidal anti-inflammatory drugs (NSAIDs) may inhibit antibody production by peripheral blood mononuclear cells; one consequence of this could be decreased effectiveness of vaccines among NSAID users. Because many older adults use low-dose aspirin for primary or secondary prevention of coronary events, any inhibitory effect of aspirin on vaccine immune response could reduce the benefits of vaccination programmes in older adults. We tested whether immune response to vaccination differed between users vs. non-users of low-dose aspirin, using data from four randomized trials of monovalent 2009 pandemic influenza A(H1N1) vaccine. Geometric mean hemagglutination inhibition (HAI) antibody titers were not significantly lower among low-dose aspirin users compared to non-users. Our results provide reassurance that influenza vaccination effectiveness is likely not reduced in older adults taking chronic low dose aspirin.
【저자키워드】 Vaccines, Influenza, Human, anti-inflammatory agents, non-steroidal,